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Literature report for anticancer drugs

Your individual project report, which should be approximately five (well-written!) pages in length, should summarize what is already known about the family of drugs that you chose for your proposal.

You must: Summarize the functional groups present in your molecules: point out which groups are lipophilic, hydrophilic, hydrogen-bond donors, hydrogen-bond acceptors, might be transformed by metabolic processes (and suggest what sort of transformations you expect), likely to cause toxicity (and suggest what sort of toxicity you might expect), etc.

Discuss in detail what has been reported in the literature about both the pharmacodynamics and pharmacokinetics associated with your molecules. As part of your discussion on the pharmacodynamics, discuss if a pharmacophore model is known or if none is contained in the literature, propose one based on the functional groups in the drug family. This portion of the report must be appropriately referenced (and you must turn in photocopies of all referenced material). Please be sure to avoid plagiarism at all costs! (We have a zero tolerance policy regarding plagiarism).


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